Oyku Gulmez, Hulya Parıldar, Ozlem Cigerli, Nilgün Guvener Demirag
Background: LA volumes and functions are reported to be independent predictors of cardiovascular events in general and diabetic population. The aim of this is to evaluate the effects of prediabetes on LA volumes and functions and parameters that effect LA volumes and functions in patients with prediabetes. Methods: 114 patients (83 female, mean age 48.6 ± 7.4 years) with prediabetes and 70 controls (46 female, mean age 46.5 ± 9.4 years) were included in the study. LA volumes (indexed maximal LA volume-Vmax, pre-atrial contraction volume-Volp, minimal LA volume-Vmin) and functions (passive emptying volume-fraction (PEV-PEF), active emptying volume-fraction (AEV-AEF), total emptying volume-fraction (TEV-TEF) were evaluated with 2- dimentional echocardiography and indexed to body surface area. Results: LA diameter, indexed Vmax, Volp, Vmin, AEV, and TEV were found to be significantly higher in preDM group compared with control group (P<0.05). There were significant positive correlation between all three LA volumes and body mass index (BMI), triglyceride, HbA1c, fasting glucose, high sensitive C-reactive protein, mitral A wave and deceleration time. Additionally, there were positive correlation between AEV, TEV and BMI. Multivariate analysis showed that the BMI had statistically significant effect on LA diameter, indexed V max, indexed Volp, indexed PEV and indexed TEV whereas prediabetes had statistically significant effect on indexed Vmax, indexed Volp and indexed Vmin. HT had only statistically significant effect on indexed Vmax. Conclusion: BMI and prediabetes have significant effect on LA volumes, but BMI is the only factor that has significant effect on LA functions. On the basis of these findings, we speculate that impairment of LA volumes and functions may be present before overt DM begins and this finding was mainly due to prediabetes and BMI.