Disruption of Nrf2 Synergizes with High Glucose to Cause Heightened Myocardial Oxidative Stress and Severe Cardiomyopathy in Diabetic Mice

Xiaoqing He and Qiang Ma

High glucose-induced oxidative stress is a major contributing mechanism to the development of diabetic cardiomyopathy. Nrf2 is an emerging critical regulator of cellular defense..Veja mais»

Editorial Next Generation Sequencing-Current Status

Suma J

Maternal Glycemia is Associated with the Perinatal Outcome in Clinical Assessments of Insulin Action in Late Pregnancy in Women at Risk for Gestational Diabetes

Loren Ekind-Hirsch

Objective: We prospectively evaluated differences in fasting- and oral glucose tolerance test (OGTT)-derived indices of insulin action in Caucasian (Cau) and Af..Veja mais»

Crohn’s Disease Presenting as Ileo-Ileal Intussusception: A Case Report

Maral Rouhani, Mohammed Rashid, Boby Sebastian, Timothy Justin

The authors present an unusual case of a 44 year old man who initially presented with urinary symptoms and underwent a CT scan of his abdomen, which..Veja mais»

Involvement of Cell Cycle and Apoptosis-Related Protein p21 in Control of Secretory Activity of Porcine Ovarian Cells

Silvia Pavlová, Dušan Vašícek, Ján Kotwica and Alexander V. Sirotkin

Protein p21, member of the Cip/Kip family of cyclin kinase inhibitors, is a physiological regulator of cell cycle, differentiation and apoptosis in various cell types. Its role ..Veja mais»

Hypopituitarism Following a Traumatic Brain Injury

Dugasa Hirpa

The most common cause of acute brain injury is trauma. In the United States, 1.5–2.0 million Traumatic Brain Injuries (TBI) occur each year, with a cost in excess of $10 b..Veja mais»