A personalized Approach for Targeting the Melanoma: Inhibition of Oncogenic Signaling in Combination with Small Molecules

Ning Yin, Muhammad AM, Syed ZH Bukhari and Syed A Ali

Melanoma is responsible for the most of skin cancer deaths each year. Standard therapies haven’t shown much efficacy against malignant melanoma. Therefore, new “individualized ..Veja mais»

Angiotensin-(1-7): A Novel Peptide to Treat Hypertension and Nephropathy in Diabetes?

Ranjit Singh Padda, Yixuan Shi, Chao-Sheng Lo, Shao-Ling Zhang and John SD Chan

The renin-angiotensin system (RAS) plays a pivotal role in mammalian

homeostasis

physiology. The RAS can be delineated into a classical RAS (the pressor arm)..Veja mais»

Elevated Angiotensin II in Rat Nodose Ganglia Primes Diabetes-Blunted Arterial Baroreflex Sensitivity: Involvement of NADPH Oxidase Derived Superoxide

Yu-Long Li

Clinical trials and experimental animal studies have confirmed the contribution of arterial baroreflex impairment in causing excess morbidity and mortality in type-1 diabetes. ..Veja mais»

Correction of Overlapping Fifth Toe Deformity with Combination of Z-Plasty and Transposition Skin Flap

Tekin Simsek, Engin Yosma, Asef Abdullayev, Bulent Demir and Ibrahim Alper Aksakal

Overlapping fifth toe is a congenital deformity and is characterized by an external rotation of the toe so that it overrides the adjacent fourth toe. Treatment of this condition..Veja mais»

Down-Selecting Numerical Weather Prediction Multi-Physics Ensembleswith Hierarchical Cluster Analysis

Jared A Lee, Haupt SE and Young GS

The goal of ensemble down selection is to retain the subset of ensemble members that span the uncertainty space of the forecast while eliminating those that are most redundant. The..Veja mais»

Erythropoietin Use and Misuse

Pooja Garg

Recombinant human erythropoietin (rhEPO) is seemingly the best restorative utilization of recombinant DNA innovation till date. It was confined in 1977 and the quality decoded i..Veja mais»