Amrane Nadia and Khaled Meghit Boumediene
Introduction: The prevalence of type 2 diabetes mellitus (DM) and obesity is actually mountingspeedily in Westernized and developing countries. Type 2 diabetes (T2D) is a complex pathology with several risk factors.It is recently known through several studies that postprandial hyperlipemia is a significant and independent risk factor for cardiovascular disease. In fact, numerous alterations in plasma lipid and lipoprotein concentrations are found in obese patients.
Method: The study, which concerned 51 patients with type 2 diabetes, took place in Diabetic Center (Ex. Gambetta) and in the division of Diabetes and Endocrinology at University Hospital (Hassani Abdelkader, Sidi-Bel-Abbès). The aim was to evaluate the relationship between the postprandial lipemia response and overweight and obesity in the type 2 diabetes. The weight, height, waist and hip circumferences, Body Mass Index (BMI) and Waist to Hip Ratio (WHR) were measured. Blood samples were analyzed for total cholesterol, glucose, triglycerides, HDL-cholesterol and LDL-c 2h after meal, fasting glucose.
Result: The obtained result determined a correlation between postprandial triglycerides concentration and the BMI especially in overweight and obese women with r 2 = 0.09 and correlation r 2 = 0.01 for men. PPHDL-c was highly elevated among women than men with a significant differences (60.44± 24.17 mg/dL vs. 43.30±18.27 mg/dL; p = 0.016).PPTG among women than men with significant differences (168.33±71.37 mg/ dL vs.121.87±60.84 mg/dL; p=003).It has been noticed that the PPHDL-c was inversely linked to fasting glucose levels (r 2 =0.07) and to the BMI values (r=0.12; p=0.34) among women.
Conclusion: The management and loss of weight still indispensible for type 2 diabetic subjects especially overweight and obese women one to avoid postprandial hypertriglyceridemia and its complications mainly coronary heart disease.