Rezaee F and Dashty M
The pathophysiology of obesity-induced metabolic syndrome is due to the dysfunction of the metabolic system. The metabolic system is composed of different components including energetic molecules, endocrine system and metabolically active tissues like adipose tissue (AT), skeletal muscles and liver. AT plays a significant role in the function of metabolic system components. Evaluation of the functionality of this system is one of the main steps in the diagnosis and determination of the severity of metabolic disorders as well as evaluation of the treatment process of patients with metabolic syndrome. In this review we have aimed to highlight the physiological role of AT as one of the fundamental components of the metabolic system and subsequently the determinants of the energy metabolic system functionality have been introduced.